American Comedy Co. San Diego in downtown San Diego's Gaslamp Quarter operates a 200-seat underground comedy club beneath Sixth Avenue, booking nationally touring headliners alongside emerging local stand-up talent. The subterranean room delivers a speakeasy-scale intimacy that concentrates audience energy around a single microphone — a smaller-format counterpart to the multi-room layout at Mad House Comedy Club a few blocks south. The lineup splits between multi-night headliner residencies on weekends and a development night for new comics, giving the room both a draw-act calendar and a pipeline for emerging performers. A full cocktail bar and kitchen serve through the performance, operating as a restaurant-entertainment hybrid with cabaret-style seating where every seat has a clear sightline to the stage. The club's position on Sixth Avenue between E and F Streets places it at the center of the Gaslamp's evening economy, one block from the craft-cocktail programming at Good Night John Boy. Full-room buyouts with custom show curation, dedicated AV, and catering accommodate corporate events and private parties seating up to 200 in the below-grade space.