House of Blues San Diego in downtown San Diego's Gaslamp Quarter occupies the former Woolworth Building at 1055 Fifth Avenue, an 1886 structure with a Roman neo-classical granite-and-terra-cotta façade converted into a 30,000-square-foot live music and dining venue. The 1,100-capacity main Music Hall and 250-seat Voodoo Room host national touring acts above a Southern-inspired restaurant floor, a concert-and-dinner format that diverges from the white-tablecloth steakhouse at Born and Raised further down Fifth Avenue. Part of the House of Blues chain founded in 1992 and now operated by Live Nation, the San Diego location launched as the brand's ninth club and has built a two-decade concert history on Fifth Avenue. The interior houses one of the largest permanently displayed collections of folk art in the country, featuring work by more than 150 self-taught artists centered on themes of racial equity and spiritual harmony. The kitchen's Gulf Coast menu — catfish, shrimp and grits, Nashville hot chicken — pulls from Delta comfort traditions far removed from the Pacific Rim seafood plating at Lionfish Modern Coastal Cuisine in the same Gaslamp corridor. Full-venue buyouts convert more than 33,000 square feet across multiple performance areas, the Delta VIP lounge, and a private greenroom into concerts, corporate receptions, and premiere parties for up to 1,500 guests.