Legendary comedy club at 916 Pearl St in La Jolla, 92037 — the original location of Mitzi Shore's nationally famous Comedy Store chain. The La Jolla outpost has hosted major stand-up talent since its founding and continues to feature touring headliners, resident comedians, and up-and-coming acts across nightly shows in a dedicated showroom on the same Pearl Street block where Dick's Liquor keeps the pre-show bottle runs convenient. Full bar service and food are available, and tickets should be purchased in advance for weekend shows. For comedy fans visiting San Diego, the La Jolla Comedy Store is a required stop — and post-show crowds looking for a proper nightcap walk Prospect to La Sala Lounge at the La Valencia.