The San Diego Healthcare Center of the AIDS Healthcare Foundation opened its Hillcrest location in 2014 and relocated to the current 3580 Fifth Avenue flagship in November 2021, co-located with an AHF Pharmacy, Wellness Center, and Out of the Closet thrift store on the Marston Hills side of the neighborhood. HIV-specialized primary care is the core service line, with PrEP and PEP prescribing, confidential HIV and STI testing, and linkage-to-care workflows serving the LGBTQ+ population that also relies on The San Diego LGBT Community Center for wraparound social services a few blocks south. The Hillcrest clinic operates on a sliding-scale model funded through pharmacy revenue, delivering care regardless of insurance status rather than requiring patient billing as the primary funding source. Primary care services extend beyond HIV management to cover general internal medicine, chronic disease management, and adult vaccinations for patients who use the clinic as their medical home. Same-day STI diagnosis with on-site treatment is handled in-house, while acute medical conditions outside the clinic''s scope route into broader urgent care coverage at operations such as Perlman Clinic San Diego up Fourth Avenue. Complex HIV cases requiring antiretroviral regimen changes, viral resistance testing, and coordination with infectious disease specialists anchor the most clinically demanding end of the caseload.