Hillcrest's flagship HIV/AIDS fundraising event organization, AIDS Walk & Run San Diego operates year-round from its headquarters at 3909 Centre St in the 92103 ZIP code. Funds raised through the annual walk and run support direct-service organizations including Being Alive, which provides peer-led programming for people living with HIV. The organization maintains wheelchair-accessible offices at its Centre Street location for year-round volunteer coordination and donor engagement. Grant-level partnerships extend to Crossroads Foundation, which channels community funding into HIV prevention and support initiatives across San Diego County. The annual event coordinates a multi-route course through Hillcrest and Balboa Park, managing road closures, medical aid stations, and same-day registration processing for several thousand participants.