Governed under the Ecumenical Patriarchate of Constantinople and the Metropolis of San Francisco, St. Spyridon Greek Orthodox Church at 3655 Park Blvd is Hillcrest's sole Eastern Orthodox parish in the 92103 ZIP code. The Byzantine-style sanctuary features traditional iconography throughout the nave, and parish events draw on Hillcrest venues such as Hillcrest Loft for receptions and community gatherings beyond the church campus. Worship follows the liturgical calendar of the Greek Orthodox Archdiocese of America, with the Divine Liturgy preceded by Orthros each week and Paraklesis services offered monthly. The parish supports charitable giving through donation networks that include Goodwill Retail Store and Donation Center in the 92103 ZIP code. St. Spyridon hosts an annual Greek Festival featuring traditional cuisine prepared by parishioners, live music, folk dancing performances, and guided tours of the sanctuary, drawing attendees from across San Diego County.