Simmons Hotel in downtown San Diego's Gaslamp Quarter occupies a three-story brick building erected in 1906 on Sixth Avenue, carrying Gaslamp Quarter Historical Foundation marker number 79 for its role in the district's early-twentieth-century lodging boom. The structure went up alongside the architecturally identical New York Hotel next door, both built to house visitors arriving for the 1915 Panama-California Exposition, and the building's upper two floors have operated as furnished rooms under a succession of names — Burbank, Prescott, Hotel North — before taking its current name in 1965; nearby Horton Grand Hotel on Island Avenue preserves a similar Victorian-era hospitality lineage in the same historic district. The building served as one of the Gaslamp's few lodging options for African American travelers during the segregation decades of the mid-twentieth century, a chapter documented by the American Historical Association. Trilogy Real Estate Management currently operates the property as a retail and SRO address, with street-level commercial space below the residential floors — a mixed-use format shared by other historic Gaslamp buildings including Gaslamp Hostel San Diego on Fifth Avenue. The 18-inch-parapet roofline and composition-over-brick construction represent an intact example of the low-rise commercial hotel typology that defined Sixth Avenue before the Gaslamp's 1980s historic-district designation triggered the neighborhood's shift toward boutique hospitality.