For life sciences and technology companies seeking integrated accounting, tax, and advisory services in downtown San Diego, CBIZ (NYSE: CBZ) anchors its national Life Sciences practice headquarters at 401 B Street. The firm's forensic consulting division handles business valuation and litigation support alongside the tax advisory group, drawing on the same regulatory depth that informs tax-controversy specialists like CI Tax Law, Inc. across the downtown corridor. CBIZ became the seventh-largest accounting firm in the United States following its 2024 acquisition of Marcum LLP, expanding to more than 9,500 team members across 23 major markets with $2.76 billion in annual revenue. The San Diego office also administers employer-sponsored retirement plans and benefits consulting, operating in the same 401(k) compliance ecosystem as 401(k) Marketing for plan design and participant education. Complex engagements at the B Street office encompass ASC 842 lease-accounting adoption, IRC Section 382 ownership-change analyses, and cross-border transfer-pricing studies under OECD guidelines for multinational life sciences clients.