ACLU San Diego & Imperial Counties in downtown San Diego's Bankers Hill district has defended constitutional rights from Fifth Avenue since the foundation's incorporation in 1990. Impact litigation drives the affiliate's four core dockets—First Amendment, equality, privacy, and due process—overlapping with the immigration defense caseload at Casa Cornelia Law Center on asylum and border-enforcement challenges. The organization's Border Humanity Project coalition spans ACLU affiliates in California, Arizona, New Mexico, and Texas, coordinating transparency and accountability campaigns along the full length of the U.S.–Mexico border. Community-facing programs include the EmpowerEd civic-education series and a Know Your Rights Ambassadors network deployed across Imperial County, building grassroots constitutional literacy in the same vein as the pro bono clinics San Diego Volunteer Lawyer Program, Inc. runs for low-income residents downtown. The affiliate's largest active cases target county-jail conditions, unlawful questioning of journalists at ports of entry, and systemic due-process failures in immigration detention facilities across both counties.