ACE Rent A Car in downtown San Diego's Middletown corridor, part of a 350-location global network launched in 1966 from ten Volkswagens in Indianapolis, operates this independently owned franchise at 2548 Kettner Boulevard between San Diego International Airport and Little Italy. Fleet turnover and interior prep between rentals taps the same mobile wash infrastructure used by providers like Romeo's Auto Spa, maintaining showroom-condition vehicles at the lot without a fixed wash bay. The Kettner Boulevard location operates outside the consolidated Rental Car Center at the airport, meaning renters pick up vehicles directly from the lot rather than riding the terminal shuttle loop. Economy sedans, compact SUVs, and full-size vans make up the fleet mix — a vehicle range backed by ACE's GDS distribution across Sabre, Apollo, and Amadeus that gives the franchise broader booking-channel reach than single-location independents like California Car Rental on the same Middletown strip. International one-way drop-off coordination across ACE's multi-country affiliate network represents the franchise's most logistically complex rental category.