San Diego Center for Design in downtown San Diego's Columbia district occupies the historic Centre City Building at 233 A Street, a 1927 reinforced-concrete structure that housed the region's medical and dental professionals for decades before transitioning to general commercial tenancy. The practice shares the Columbia district's architectural corridor with ACRM Architects + Interiors, both operating within walking distance of the waterfront and the San Diego Convention Center. Situated at the intersection of A Street and Third Avenue near the Embarcadero, the office anchors a design practice in a district where pre-war commercial buildings provide the kind of high-ceiling, natural-light studio space that architecture firms require for physical model work and material review. The same Columbia corridor connects to the residential and institutional design scope at Warner Architecture & Design, extending the neighborhood's concentration of architecture practices between Broadway and the Harbor Drive waterfront. The Centre City Building's own fourteen-story L-plan configuration — granite-clad lower floors supporting brick-faced upper stories on a ductile concrete frame — offers a working case study in early-twentieth-century structural engineering and facade-material transitions.