Affiliated with UC San Diego Health, South Bay Radiation Oncology in Chula Vista delivers advanced radiation therapy from 959 Lane Avenue in the Eastlake corridor, staffing four radiation oncologists who treat head-and-neck, prostate, breast, CNS, and skin malignancies. Head-and-neck cancer patients requiring radiation to the oral cavity or mandible undergo pre-treatment dental clearance to mitigate osteoradionecrosis risk, a protocol that connects the center to general dentistry providers including Bonita Dental Center for pre-radiation extraction and fluoride tray fabrication. The facility runs linear accelerators configured for intensity-modulated radiation therapy, image-guided radiation therapy, stereotactic body radiation therapy, and cranial stereotactic radiosurgery — techniques refined through UC San Diego's NCI-designated Comprehensive Cancer Center research pipeline. Electronic brachytherapy delivers targeted surface radiation for non-melanoma skin cancers using applicator-based dose delivery, eliminating the need for surgical excision in select basal cell and squamous cell carcinoma cases. Cancer patients managing radiation-induced nausea, fatigue, and neuropathic discomfort incorporate integrative modalities at providers including South Bay Family Acupuncture, where acupuncture protocols target treatment side effects alongside conventional oncologic care. The center's highest-acuity treatments include single-fraction cranial stereotactic radiosurgery delivering 18 to 24 Gy to metastatic brain lesions under sub-millimeter targeting precision, and five-fraction SBRT protocols for early-stage non-small-cell lung carcinoma.